Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5654920 | Clinical Immunology | 2017 | 33 Pages |
Abstract
Common variable immunodeficiency (CVID) is a primary immunoglobulin deficiency characterized by recurrent infections and complications, including autoimmunity, enteropathy, polyclonal lymphocytic infiltration or lymphoid malignancy. Innate T cells can support B cell maturation and antibody production. We investigated the numbers, phenotypes and functions of circulating B cell, γδ T cell, invariant natural killer T (iNKT) cell and mucosal-associated invariant T (MAIT) cell subsets in 23 CVID patients and 27 healthy controls. Switched-memory B cells and plasmablasts were depleted in CVID patients (p < 0.0001). γδ T cells were found at normal numbers, but iNKT and MAIT cells were depleted (p < 0.0001 and p < 0.002). MAIT cells were especially low in patients with complicated CVID (p < 0.05). MAIT cells from patients appeared more activated and more frequently produced interleukin-17A, interleukin-22 and tumor necrosis factor-α than MAIT cells from healthy subjects in vitro. Thus, MAIT cell depletion and activation may contribute to immunodeficiency and complications associated with CVID.
Keywords
ESIDtransmembrane activator and CAML interactorICOSBAFF-RMAIT cellsTACIiNKTMucosal-associated invariant TCVIDphorbol 12-myristate 13-acetatemAbIFN-γHMB-PPTCrnatural killerPMAγδ T cellsMonoclonal antibodyEuropean Society for ImmunodeficienciesInnate immunityinterferon-γinterleukinPLItumor necrosis factor-αiNKT cellsinvariant natural killer TTNF-αmajor histocompatibility complexMHCMAITCommon variable immunodeficiencyT cell receptor
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Authors
Serena Arduini, Jean Dunne, Niall Conlon, Conleth Feighery, Derek G. Doherty,