| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5654927 | Clinical Immunology | 2017 | 32 Pages |
Abstract
The B-cell compartment in APDS patients is affected by the mutations in PI3K. There is reduced differentiation beyond the transitional stage, increased AKT phosphorylation and increased apoptosis. This B-cell phenotype contributes to the clinical phenotype.
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Authors
Marjolein Wentink, Virgil Dalm, Arjan C. Lankester, Pauline A. van Schouwenburg, Liesbeth Schölvinck, Tomas Kalina, Radana Zachova, Anna Sediva, Annechien Lambeck, Ingrid Pico-Knijnenburg, Jacques J.M. van Dongen, Malgorzata Pac, Ewa Bernatowska,