Article ID Journal Published Year Pages File Type
5656522 Journal de Gynécologie Obstétrique et Biologie de la Reproduction 2016 6 Pages PDF
Abstract
The number of invasive procedures decreased significantly (P < 0.0001) between 2012 (n = 1177, i.e. 42 % of the global activity of the Prenatal Diagnosis Center at the AHP in 2012) and 2013 (n = 987 or 28.5 %) and between 2013 and 2014 (n = 599 or 23.4 %). The NIPT calculated performance statistics are: sensitivity ≥ 99.9 %; specificity = 99.8 %; Positive Predictive Value = 90.4 %; Negative Predictive Value ≥ 99.9 %; False Positives = 3. While the actual screening statistic values are: sensitivity ≥ 95.4 %; specificity = 82.5 %; Positive Predictive Value = 6.5 %; Negative Predictive Value = 99.9 %; False Positives = 1197. The NIPT has reduced the number of invasive procedures at the Prenatal Diagnosis Center at the AHP. The NIPT performances are superior to those of the actual screening.
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