Quand demander un bilan génétique devant une hypertriglycéridémie ?

Hypertriglyceridemia represent a very heterogeneous set of dyslipidemia both at the phenotypic as at the mechanistic level. Indeed, they may be isolated or mixed, minor, moderate or major, combining variable proportions of genetic and secondary factors. Hypertriglyceridemia are common and usually secondary to environmental factors; genetic exploration therefore should not be systematic before the discovery of hypertriglyceridemia. The realization of genetics tests can be a diagnosis aid and support for a minority of hypertriglyceridemia. We must identify and select carefully the information to not generate a significant waste of genetic tests and be faced with a multitude of polymorphisms hard to explain without tangible clinical fallout.