| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5657664 | Clinical Gastroenterology and Hepatology | 2017 | 29 Pages |
Abstract
In analysis of data from the DILIN prospective study, we found that most cases of DILI attributed to nitrofurantoin or minocycline and about half of cases that were due to methyldopa and hydralazine have a phenotype of autoimmunity similar to AIH. These features decrease with recovery of the injury and are not associated with the typical HLA alleles found in patients with idiopathic AIH.
Keywords
ULNIgGAIHSLAupper limit of the normal rangeALTASTAspartate aminotransferaseDrug-induced liver injuryAlanine aminotransferaseAlkaline phosphataseantinuclear antibodysmooth muscle antibodySoluble liver antigenANAimmunoglobulin immunoglobulin GDatabase AnalysisELISAEnzyme-linked immunosorbent assaySMADILIDILINToxicityHepatotoxicityDrug-Induced Liver Injury NetworkAutoimmune hepatitisImmune response
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
Ynto S. de Boer, Andrzej S. Kosinski, Thomas J. Urban, Zhen Zhao, Nanye Long, Naga Chalasani, David E. Kleiner, Jay H. Hoofnagle, Drug-Induced Liver Injury Network Drug-Induced Liver Injury Network,