| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658139 | Gastroenterology | 2017 | 32 Pages |
Abstract
Local ROCK inhibition prevents and reverses intestinal fibrosis by diminishing MRTF and p38 MAPK activation and increasing autophagy in fibroblasts. Overall, our results show that local ROCK inhibition is promising for counteracting fibrosis as an add-on therapy for CD.
Keywords
TNFECMSCIDIBDqRT-PCRCTGFTGFDSSMCP1HIFαSMAATG16L1MRTFMyocardin-related transcription factorMMPalpha smooth muscle actinColitisinterferonIFNinterleukinCrohn’s diseaseInflammatory bowel diseasetransforming growth factorStenosisEMTintraperitonealMesenchymal cellsDextran sulfate sodiumConnective tissue growth factortumor necrosis factorExtracellular matrixmatrix metalloproteinasequantitative real-time polymerase chain reactionsevere combined immunodeficientUlcerative colitisepithelial-to-mesenchymal transitionRock
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Authors
Tom Holvoet, Sarah Devriese, Karolien Castermans, Sandro Boland, Dirk Leysen, Yves-Paul Vandewynckel, Lindsey Devisscher, Lien Van den Bossche, Sophie Van Welden, Melissa Dullaers, Roosmarijn E. Vandenbroucke, Riet De Rycke, Karel Geboes, Arnaud Bourin,