Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5658140 | Gastroenterology | 2017 | 43 Pages |
Abstract
Using the Plp1 promoter to selectively eliminate glia in mice, we found that enteric glia are not required for maintenance of the intestinal epithelium, but are required for regulation of intestinal motility in females. Previous observations supporting the concept that maintenance of the intestinal epithelium requires enteric glia can be attributed to non-glial toxicity in GfapHSV-TK mice and epithelial-cell expression of GFAP. Contrary to widespread notions, enteric glia are therefore not required for epithelial homeostasis. However, they regulate intestinal motility in a sex-dependent manner.
Keywords
ICCDSSDTAFITCHSV-tkENSColonic migrating motor complexMLNDPTSex differencesGITTCNSGastrointestinal transit timeinterstitial cells of Cajaldextran sodium sulfateenteric nervous systemcentral nervous systemfluorescein isothiocyanateEpithelial barrierHerpes simplex virus thymidine kinasemesenteric lymph node
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Authors
Meenakshi Rao, Daniella Rastelli, Lauren Dong, Sophia Chiu, Wanda Setlik, Michael D. Gershon, Gabriel Corfas,