| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658145 | Gastroenterology | 2017 | 39 Pages |
Abstract
Proliferative LGR5 cells are an intermediate stem cell population in the liver that emerge only during tissue injury. In contrast, LRCs are quiescent stem cells that are present in homeostatic liver, respond to tissue injury, and can give rise to LGR5 stem cells, as well as SOX9- and CD44-positive cells.
Keywords
Label-retaining cellLGR5leucine-rich repeat-containing G-protein coupled receptor 5LRCYFPDTRrtTACCl4qRT-PCRFACSGFPDOXBrdUbromodeoxyuridineTAMtamoxifenReverse tetracycline transactivatordiphtheria toxindoxycyclineLiver stem cellsfluorescence-activated cell sorterQuantitative reverse-transcriptase polymerase chain reactionyellow fluorescent proteingreen fluorescent proteinCarbon tetrachlorideDiphtheria Toxin Receptor
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Authors
Wanlu Cao, Kan Chen, Michiel Bolkestein, Yuebang Yin, Monique M.A. Verstegen, Marcel J.C. Bijvelds, Wenshi Wang, Nesrin Tuysuz, Derk ten Berge, Dave Sprengers, Herold J. Metselaar, Luc J.W. van der Laan, Jaap Kwekkeboom, Ron Smits,