| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658201 | Gastroenterology | 2016 | 62 Pages |
Abstract
In mice, we found that LPS-induced inflammation increases blood levels of MIR122, which reduces expression of Epo in the kidney; this is a mechanism of inflammation-induced anemia. Strategies to block MIR122 in patients with inflammation could reduce the development or progression of anemia.
Keywords
NF-κBPHZMicroRNA-122EPOmRNATSSLPSTNFαRed blood cellsC/EBPαHCCmessenger RNAerythropoietinmiR-122tumor necrosis factor αIntraperitoneallytranscription start siterhEPOnuclear factor-κBPhenylhydrazinelipopolysaccharideMouse modelUTR یا untranslated regions untranslated regionMicrobiomeknockoutNash Hepatocellular carcinoma
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Authors
Mila Rivkin, Alina Simerzin, Elina Zorde-Khvalevsky, Chofit Chai, Jonathan B. Yuval, Nofar Rosenberg, Rona Harari-Steinfeld, Ronen Schneider, Gail Amir, Reba Condiotti, Mathias Heikenwalder, Achim Weber, Christoph Schramm, Henning Wege, Johannes Kluwe,