| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658258 | Gastroenterology | 2017 | 39 Pages |
Abstract
HIF1A represses, whereas p53 increases, expression of MIR34A in CRC cells. MIR34A reduces expression of PPP1R11 to prevent activation of STAT3 and inhibit the EMT and metastasis. Strategies to target this pathway might be developed to inhibit CRC metastasis and overcome resistance to therapy associated with hypoxia.
Keywords
STAT3hypoxia inducible factor 1 alpha subunitCobalt (II) chlorideVIMHRECoCl2VimentinDOXFBS5-FU5-fluoro-uracilHIF1aSmall interfering RNAsiRNAmesenchymal-epithelial transitionEMTdoxycyclineColorectal cancerColon cancerfetal bovine serumChemo-resistanceHypoxia-response elementSignal transducers and activators of transcription 3METUTR یا untranslated regions untranslated regionMicroRNAMiRNASignal transductionSMSTumor progressionCRCepithelial-to-mesenchymal transition
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Authors
Huihui Li, Matjaz Rokavec, Longchang Jiang, David Horst, Heiko Hermeking,