Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5658262 | Gastroenterology | 2017 | 37 Pages |
Abstract
In a cell culture system, we found TNF to have antiviral effects independently of, as well as in combination with, IFNs. TNF inhibits HCV infection despite increased HCV envelope glycoprotein-mediated infection of liver cells. These findings contradict those from other studies, which have reported that TNF blocks signal transduction in response to IFNs. The destructive inflammatory effects of TNF must be considered along with its antiviral effects.
Keywords
median tissue culture infectious dosePBSTNFαHflCTCID50HCVppHCVccTNFRRLUDAADAPI4′,6-diamidino-2-phenylindoleMOIInnate immunityinterferonIFNLiver diseasetumor necrosis factor αViral infectionImmune regulationHBVHepatitis C virusHCVrelative light unitshepatitis B virusmultiplicity of infectiontumor necrosis factor receptor
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Authors
Stephen M. Laidlaw, Svetlana Marukian, Rachel H. Gilmore, Siobhán B. Cashman, Volodymyr Nechyporuk-Zloy, Charles M. Rice, Lynn B. Dustin,