Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5658360 | Gastroenterology | 2017 | 41 Pages |
Abstract
In a bioinformatics search for agents that alter the HCC-specific gene expression pattern, we identified the anthelmintic niclosamide as a potential anti-tumor agent. Its ethanolamine salt, with greater bioavailability, was more effective than niclosamide at slowing the growth of genetically induced liver tumors and patient-derived xenografts in mice. Both agents disrupted interaction between cell division cycle 37 and heat shock protein 90 in HCC cells, with concomitant inhibition of their downstream signaling pathways. NEN might be effective for treatment of patients with HCC.
Keywords
PDXIC30Cancer Cell Line EncyclopediaFDACdc37CCLENENLINCSTCGACMAPHSP90EGFRGEOIC5050% inhibitory concentrationHCCPatient-derived xenograftα-fetoproteinMitochondrial uncouplerThe cancer genome atlasAFPTreatmentFood and Drug AdministrationLiver cancerconnectivity mapHeat shock protein 90Gene Expression OmnibusHepatocellular carcinomaBig DataEpidermal growth factor receptor
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Authors
Bin Chen, Wei Wei, Li Ma, Bin Yang, Ryan M. Gill, Mei-Sze Chua, Atul J. Butte, Samuel So,