Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5658421 | Gastroenterology | 2017 | 10 Pages |
Abstract
In phase 3 trials of patients with HCV infection, we did not establish that sofosbuvir-velpatasvir-voxilaprevir for 8 weeks was noninferior to sofosbuvir-velpatasvir for 12 weeks, but the 2 regimens had similar rates of SVR in patients with HCV genotype 3 and cirrhosis. Mild gastrointestinal adverse events were associated with treatment regimens that included voxilaprevir. ClinicalTrials.gov numbers: POLARIS-2, NCT02607800; and POLARIS-3, NCT02639338.
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Authors
Ira M. Jacobson, Eric Lawitz, Edward J. Gane, Bernard E. Willems, Peter J. Ruane, Ronald G. Nahass, Sergio M. Borgia, Stephen D. Shafran, Kimberly A. Workowski, Brian Pearlman, Robert H. Hyland, Luisa M. Stamm, Evguenia Svarovskaia, Hadas Dvory-Sobol,