| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658424 | Gastroenterology | 2017 | 54 Pages |
Abstract
In studies of human and mouse ENS progenitors, we found activation of the Wnt signaling pathway to promote neurogenesis of the ENS in vitro. The neurogenic effect of Wnt agonists on ENS progenitors supports their use in generation of cell pools for autologous cell replacement therapies.
Keywords
FACSENSGSK-3qRT-PCRbFGFLRPmRNA5-bromo-2′-deoxyuridine5-ethynyl-2′-deoxyuridineDMSOEdUmessenger RNABrdUProliferationDifferentiationfluorescence-activated cell sortingDimethyl sulfoxideenteric nervous systembasic fibroblast growth factorNeuronsquantitative reverse transcription polymerase chain reactionNeural progenitorglycogen synthase kinase-3
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Authors
Ying Zhang, Karin Seid, Florian Obermayr, Lothar Just, Peter H. Neckel,