| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658425 | Gastroenterology | 2017 | 34 Pages |
Abstract
We analyzed mutations and gene copy number changes in nontumor, IEN, and ESCC samples, collected from 70 patients. IEN and ESCCs each had similar mutations and markers of genomic instability, including apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like. Genomic changes observed in precancerous lesions might be used to identify patients at risk for ESCC.
Keywords
phosphorylated H2AXCNAEACWGSTRSESCCIENAPOBECgDNAWESγH2AXgenomic DNAEsophageal adenocarcinomaloss of heterozygosityTargeted sequencingWhole-exome sequencingWhole-genome sequencingsequencingDriver mutationCarcinogenesisLOHEsophagusIntraepithelial neoplasiaEsophageal squamous cell carcinomaCopy number alteration
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Authors
Xi Liu, Min Zhang, Songmin Ying, Chong Zhang, Runhua Lin, Jiaxuan Zheng, Guohong Zhang, Dongping Tian, Yi Guo, Caiwen Du, Yuping Chen, Shaobin Chen, Xue Su, Juan Ji, Wanting Deng, Xiang Li, Shiyue Qiu, Ruijing Yan, Min Su,