| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658427 | Gastroenterology | 2017 | 79 Pages |
Abstract
In CAFs isolated from human DGCs, we observed increased expression of RHBDF2, which regulates TGFB1 signaling. Expression of RHBDF2 in fibroblasts is induced by inflammatory cytokines (such as IL1A, IL1B, and tumor necrosis factor) secreted by DGCs. RHBDF2 promotes cleavage of TGFBR1 by activating TACE and motility of CAFs in response to TGFB1. These highly motile CAFs induce DGCs to invade extracellular matrix and lymphatic vessels in nude mice.
Keywords
NFsDGCECMqRT-PCRTACETGFCAFsIGCDiffuse-type gastric cancerTNFα-SMARNAseqTNF-alpha converting enzymesmall interfering RNAssiRNAAlpha-smooth muscle actinTumor stromainflammationstandard deviationinterleukintransforming growth factorRNA sequencingEMTintracellular domainICDStomach cancerGastric cancerTumor cellsConditioned mediumtumor necrosis factorCancer-associated fibroblastsExtracellular matrixquantitative reverse-transcription polymerase chain reactionepithelial-to-mesenchymal transitionLymph node
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Authors
Takatsugu Ishimoto, Keisuke Miyake, Tannistha Nandi, Masakazu Yashiro, Nobuyuki Onishi, Kie Kyon Huang, Suling Joyce Lin, Ramnarayanan Kalpana, Su Ting Tay, Yuka Suzuki, Byoung Chul Cho, Daisuke Kuroda, Kota Arima, Daisuke Izumi, Masaaki Iwatsuki,