| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658430 | Gastroenterology | 2017 | 60 Pages |
Abstract
In studies of mice with chronic liver injury, we showed the antifibrotic effects of repeated infusions of purified HSCs. We found that HSCs promote recruitment of endogenous macrophages and neutrophils. Strategies to reduce SIP signaling and increase retention of HSCs in the liver could increase their antifibrotic activities and be developed for treatment of patients with liver fibrosis.
Keywords
CCR2SGPL1common myeloid progenitors1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodideKSLCommon lymphoid progenitorsSphK1CFSECCLα-SMAS1PAPCHSCMMPPSRCLPCMPDIrpicrosirius redallophycocyaninSphingosine-1-phosphate lyasesphingosine 1-phosphatesphingolipidα-smooth muscle actinHematopoietic stem cellchemokine (C-C motif) ligandmatrix metalloproteinaseMouse modelbone marrowcarboxyfluorescein succinimidyl ester
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Authors
Andrew King, Diarmaid D. Houlihan, Dean Kavanagh, Debashis Haldar, Nguyet Luu, Andrew Owen, Shankar Suresh, Nwe Ni Than, Gary Reynolds, Jasmine Penny, Henry Sumption, Prakash Ramachandran, Neil C. Henderson, Neena Kalia, Jon Frampton, David H. Adams,