| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658433 | Gastroenterology | 2017 | 79 Pages |
Abstract
Human PDACs have increased levels of 5-HT, and PDAC cells increase expression of its receptor, HTR2B. These increases allow for tumor glycolysis under metabolic stress and promote growth of pancreatic tumors and PDAC xenograft tumors in mice.
Keywords
5-HTHTRs5-HT2BMAOAPDXKPCSFKTph5-hydroxytryptamineECARmTORSrc family kinasePatient-derived xenograftPancreatic ductal adenocarcinomaPDAC یا pancreatic ductal adenocarcinomaimmunohistochemicalIHCcomputed tomographyPositron emission tomographyserotonin (5-hydroxytryptamine)monoamine oxidase Apancreatic intraepithelial neoplasiamammalian target of rapamycintryptophan hydroxylasePanINPET5-HT receptors
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Authors
Shu-Heng Jiang, Jun Li, Fang-Yuan Dong, Jian-Yu Yang, De-Jun Liu, Xiao-Mei Yang, Ya-Hui Wang, Min-Wei Yang, Xue-Liang Fu, Xiao-Xin Zhang, Qing Li, Xiu-Feng Pang, Yan-Miao Huo, Jiao Li, Jun-Feng Zhang, Ho-Young Lee, Su-Jae Lee, Wen-Xin Qin,