| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658434 | Gastroenterology | 2017 | 71 Pages |
Abstract
We found expression of the snoRNA SNORA23, which mediates sequence-specific pseudouridylation of ribosomal RNAs, to be increased in human PDAC tissues compared with non-tumor tissues, and levels to correlate with tumor invasion grade and patient survival time. SNORA23 increases expression of SYNE2, possibly through modulation of ribosome biogenesis, to promote PDAC cell survival and invasion, and growth and metastasis of xenograft tumors in mice.
Keywords
qRT-PCRHLMCleucine-rich repeat-containing G-protein coupled receptor 5MCNIPMNsnoRNAASOmRNApDNAIPOcDNACeAComplementary DNAantisense oligonucleotidemessenger RNASmall interfering RNANon-coding RNAsiRNAPancreatic ductal adenocarcinomaPDAC یا pancreatic ductal adenocarcinomacarcinoembryonic antigenOncogenePancreatic cancerLiver metastasisMicroRNAMiRNAintraductal papillary mucinous neoplasmmucinous cystic neoplasmPlasmid DNA
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Authors
Lin Cui, Kenji Nakano, Sumalee Obchoei, Kiyoko Setoguchi, Masaki Matsumoto, Tsuyoshi Yamamoto, Satoshi Obika, Kazuaki Shimada, Nobuyoshi Hiraoka,