| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658550 | Gastroenterology | 2017 | 53 Pages |
Abstract
In an analysis of rectal tissues from treatment-naive pediatric patients with IBD, we observed activation of a type 2 immune response during the early course of UC. We were able to distinguish patients with UC from those with colon-only CD based on increased mucosal expression of genes that mediate type 2 and type 17 immune responses. Increased expression at diagnosis of genes that mediate a type 2 immune response is associated with response to therapy and remission in pediatric patients with UC.
Keywords
RHIPGAAUROCCDCTNFinducible T-cell costimulatorRT-qPCRIBDICOSIfnginterferon-γinterleukinCrohn’s diseaseInflammatory bowel diseaseRiskPrognostic factorconfidence intervaltumor necrosis factorImmune regulationodds ratioquantitative reverse-transcription polymerase chain reactionGene expression profilequantification cycleUlcerative colitis
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Authors
Michael J. Rosen, Rebekah Karns, Jefferson E. Vallance, Ramona Bezold, Amanda Waddell, Margaret H. Collins, Yael Haberman, Phillip Minar, Robert N. Baldassano, Jeffrey S. Hyams, Susan S. Baker, Richard Kellermayer, Joshua D. Noe, Anne M. Griffiths,