| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658557 | Gastroenterology | 2017 | 62 Pages |
Abstract
Levels of P anaerobius are increased in human colon tumor tissues and adenomas compared with non-tumor tissues; this bacteria increases colon dysplasia in a mouse model of CRC. PÂ anaerobius interacts with TLR2 and TLR4 on colon cells to increase levels of reactive oxidative species, which promotes cholesterol synthesis and cell proliferation.
Keywords
HMGCSPCNASREBP2TLRqPCRazoxymethaneNADPHNACN-acetyl-l-cysteineAOMHMG-CoA synthaseROSProliferating Cell Nuclear AntigenBrdUbromodeoxyuridinePathogenToll-like receptorColorectal cancerColon cancerMicrobiotanicotinamide adenine dinucleotide phosphateSignal transductionquantitative polymerase chain reactionsterol regulatory element-binding protein 2CRCReactive oxidative species
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Authors
Ho Tsoi, Eagle S.H. Chu, Xiang Zhang, Jianqiu Sheng, Geicho Nakatsu, Siew C. Ng, Anthony W.H. Chan, Francis K.L. Chan, Joseph J.Y. Sung, Jun Yu,