| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658558 | Gastroenterology | 2017 | 46 Pages |
Abstract
Levels of MIR301A are increased in IECs from patients with active IBD. MIR301A reduces expression of BTG1 to reduce epithelial integrity and promote inflammation in mouse colon and promotes tumorigenesis. Strategies to decrease levels of MIR301A in colon tissues might be developed to treat patients with IBD and CAC.
Keywords
IBDTNFT-helperBTG1CACazoxymethaneDSSMIRPCNAAOMProliferating Cell Nuclear AntigeninterleukinCrohn’s diseaseCrohn's diseaseInflammatory bowel diseaseTransgenicColorectal cancercolitis-associated cancerIntestinal epithelial cellsDextran sulfate sodiumtumor necrosis factorMouse modelImmune regulationMicroRNApolymerase chain reactionPCRCRCIECUlcerative colitis
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Authors
Chong He, Tianming Yu, Yan Shi, Caiyun Ma, Wenjing Yang, Leilei Fang, Mingming Sun, Wei Wu, Fei Xiao, Feifan Guo, Minhu Chen, Hong Yang, Jiaming Qian, Yingzi Cong, Zhanju Liu,