| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658559 | Gastroenterology | 2017 | 38 Pages |
Abstract
In an analysis of serum metabolomes of patients with NAFLD and MAT1A-KO mice with steatohepatitis, we identified 2 major subtypes of NAFLD and markers that differentiate steatosis from NASH in each subtype. These might be used to monitor disease progression and identify therapeutic targets for patients.
Keywords
ALTNAFLDVLDLJC-1DMRGSHPCAAlanine aminotransferaseS-adenosylmethioninenonalcoholic steatohepatitisFatty acidsNonalcoholic fatty liver diseasePrincipal component analysisTriglyceridesDiglyceridesMass spectrometryphosphatidylcholinephosphatidylethanolaminevery-low-density lipoproteinLipid metabolismMouse modelNash wild-typePrognosticliquid chromatographyGlutathioneSAMe
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Authors
Cristina Alonso, David Fernández-Ramos, Marta Varela-Rey, Ibon MartÃnez-Arranz, Nicolás Navasa, Sebastiaan M. Van Liempd, José L. LavÃn Trueba, Rebeca Mayo, Concetta P. Ilisso, Virginia G. de Juan, Marta Iruarrizaga-Lejarreta, Laura delaCruz-Villar,