| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658562 | Gastroenterology | 2017 | 72 Pages |
Abstract
Autophagic PSCs produce ECM molecules and interleukin 6 and are associated with shorter survival times and disease recurrence in patients with pancreatic cancer. Inhibitors of PSC autophagy might reduce pancreatic tumor invasiveness by altering the tumor stroma.
Keywords
αSMATGFLC3PCNApancreatic cancer cellPSCRT-PCRshRNAmRNAPCCHSCECMmessenger RNASmall interfering RNAsmall hairpin RNAsiRNAProliferating Cell Nuclear Antigenα-smooth muscle actininterleukintransforming growth factorlight chain 3Hepatic stellate cellpancreatic stellate cellCytokineFibronectinExtracellular matrixreverse transcription polymerase chain reactionTumor progressionCol1Chloroquine
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Authors
Sho Endo, Kohei Nakata, Kenoki Ohuchida, Shin Takesue, Hiromichi Nakayama, Toshiya Abe, Kazuhiro Koikawa, Takashi Okumura, Masafumi Sada, Kohei Horioka, Biao Zheng, Yusuke Mizuuchi, Chika Iwamoto, Masaharu Murata, Taiki Moriyama, Yoshihiro Miyasaka,