| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658690 | Gastroenterology | 2017 | 37 Pages |
Abstract
We found inflammatory cytokines to reduce the activities of miRNAs. In mice with colitis, activities of miRNAs are reduced; administration of an agent that increases miRNA function prevents colon tumor formation in these mice. This pathway might be targeted to prevent colon carcinogenesis in patients with inflammatory bowel diseases.
Keywords
Rho-associated, coiled-coil containing protein kinaseIBDAOMazoxymethaneGEOGFPMEFDSSIL1bmRNAIL1ATNFmessenger RNAArgonaute 2Ago2interleukininterleukin 1αinterleukin 1βGene regulationRISCDextran sulfate sodiumtumor necrosis factorRNA-Induced Silencing ComplexMouse modelPost-transcriptional regulationUTR یا untranslated regions untranslated regionmouse embryonic fibroblastMicroRNAMiRNAgreen fluorescent proteinGene Expression OmnibusRock
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
Takeshi Yoshikawa, Jianfeng Wu, Motoyuki Otsuka, Takahiro Kishikawa, Nobumi Suzuki, Akemi Takata, Motoko Ohno, Rei Ishibashi, Mari Yamagami, Ryo Nakagawa, Naoya Kato, Masaaki Miyazawa, Jiahuai Han, Kazuhiko Koike,