| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658728 | Gastroenterology | 2017 | 29 Pages |
Abstract
Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling. We review how TGF-β family member signaling is altered during development of colorectal cancer, models of study, interaction of pathways, and potential therapeutic strategies.
Keywords
TNFGSK3BJPSHHTActivinMSITGF15-hydroxyprostaglandin dehydrogenaseinterleukinMicrosatellite instabilitytransforming growth factorTransforming growth factor βHereditary hemorrhagic telangiectasiaEMTGastrointestinalColorectal cancerColon cancerjuvenile polyposis syndrometumor necrosis factorBMPBone morphogenetic proteinCRCepithelial-to-mesenchymal transitionGlycogen synthase kinase 3β
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Authors
Barbara Jung, Jonas J. Staudacher, Daniel Beauchamp,