Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5658929 | Gastroenterology | 2017 | 21 Pages |
Abstract
Using sequencing and gene expression analyses, we identified a subgroup of HCA characterized by fusion of the INHBE and GLI1 genes and activation of sonic hedgehog pathway. Molecular subtypes of HCAs associated with different patients' risk factors for HCA, disease progression, and pathology features of tumors. This classification system might be used to select treatment strategies for patients with HCA.
Keywords
IHCACTNNB1GLI1GNASHNF1Ahepatocyte nuclear factor 1ASAAUHCAInflammatory hepatocellular adenomaRT-PCRFRKJanus kinaseHCCSTATinterleukinTERTTelomerase reverse transcriptaseBenignShhserum amyloid Abody mass indexBMISignal transducer and activator of transcriptionodds ratioreverse transcription polymerase chain reactionTumor progressionOral contraceptionJAKHepatocellular carcinoma
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Authors
Jean-Charles Nault, Gabrielle Couchy, Charles Balabaud, Guillaume Morcrette, Stefano Caruso, Jean-Frederic Blanc, Yannick Bacq, Julien Calderaro, Valérie Paradis, Jeanne Ramos, Jean-Yves Scoazec, Viviane Gnemmi, Nathalie Sturm, Catherine Guettier,