Article ID Journal Published Year Pages File Type
5658977 Gastroenterology 2016 44 Pages PDF
Abstract
A large proportion of HCC samples were found to overexpress IGF2, via demethylation of its fetal promoter. Overexpression of IGF2 accelerates formation of liver tumors in mice with hepatic expression of MYC and AKT1, via activation of IGF1 receptor signaling. An antibody against IGF1 and IGF2 slows growth of xenograft tumors and increases survival of these mice.
Related Topics
Health Sciences Medicine and Dentistry Gastroenterology
Authors
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