| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5658979 | Gastroenterology | 2016 | 36 Pages |
Abstract
In gene expression profile analysis of PDAC samples, we found the DRD2 signaling pathway to be activated. Inhibition of DRD2 in pancreatic cancer cells reduced proliferation and migration, and slowed growth of xenograft tumors in mice. DRD2 antagonists routinely used for management of schizophrenia might be tested in patients with pancreatic cancer.
Keywords
CSCFDADRD2UPRGPCRpKashRNATMAcAMPDMSOshort hairpin RNACyclic adenosine monophosphatePancreatic ductal adenocarcinomaPDAC یا pancreatic ductal adenocarcinomaDrug repositioningDimethylsulfoxideFood and Drug AdministrationCancer stem cellsendoplasmic reticulumUnfolded protein responsechronic pancreatitisPancreasprotein kinase Aprotein kinase RNA-like endoplasmic reticulum kinasePERKdopamine receptor D2
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Authors
Pouria Jandaghi, Hamed S. Najafabadi, Andrea S. Bauer, Andreas I. Papadakis, Matteo Fassan, Anita Hall, Anie Monast, Magnus von Knebel Doeberitz, John P. Neoptolemos, Eithne Costello, William Greenhalf, Aldo Scarpa, Bence Sipos, Daniel Auld,