Molecular cytology genotyping of primary and metastatic GIÂ stromal tumors by using a custom two-gene targeted next-generation sequencing panel with therapeutic intent

Our data have demonstrated the ability to stratify either primary or metastatic gastrointestinal stromal tumors by mutational subtype using a targeted next-generation sequencing 2 gene mutation panel. We highlight the ability to use cytology specimens obtained via minimally invasive techniques as a surrogate to surgical specimens given the high mutational landscape concordance between paired specimens.