Oxidized phospholipids exert a dual effect on bile acid-induced CCL2 expression in pancreatic acini

Article ID	Journal	Published Year	Pages	File Type
5661138	Pancreatology	2017	36 Pages	PDF

Abstract

oxPOPC exerts pro- and anti-inflammatory effects in pancreatic acinar cells mediated by TLR4 and PPARÎ³ signals, respectively. This dual action proved to be dependent on the concentration. The molecular mechanisms involved in the oxPL response could be useful for new therapeutic approaches to the treatment of oxPLs-related inflammatory pathologies.

Keywords

CCL2 TLR4 NF-κB TLR PPARγ PPAR Janus kinase STAT Fatty acid Inflammatory gene expression Toll-like receptor Pancreatic acinar cells Nuclear factor-kappa B oxidized phospholipids Signal transducer and activator of transcription JAK chemokine (C-C motif) ligand 2 peroxisome proliferator-activated receptor