Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5663574 | Acta Haematologica Polonica | 2017 | 5 Pages |
Abstract
Ixazomib is a new agent registered in combination with lenalidomide and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. The drug is the first oral proteasome inhibitor. Registration data show improvement in progression-free survival time (20.6 vs 14.7 months, p = 0.01) but recent analysis in Asian population also in overall survival (25.8 vs 15.8 months, HR = 0.419, p = 0.001) what placed with lack of ixazomib incremental toxicity may implicate clinical importance of the treatment in relapsed or refractory multiple myeloma. Oral dosing of the triplet regimen may decrease the number and duration of hospitalizations that allows for better social functioning and occupational performance, and thus impacts daily disease perception.
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Authors
Krzysztof Giannopoulos, WiesÅaw Wiktor JÄdrzejczak, Krzysztof Jamroziak, Dominik Dytfeld, Tadeusz Robak, Andrzej Hellmann,