Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5664247 | Current Problems in Cancer | 2016 | 13 Pages |
Abstract
HER2 is over-expressed or amplified in 15-20% of breast cancer. Significant progress has been made in the treatment of metastatic HER2+ breast cancer. This is largely due to successful targeting of the HER2 pathway. There are several approved agents in the metastatic setting. However, treatment resistance frequently develops and tumors eventually progress. In recent years, our understanding of mechanisms of resistance has evolved. It is generally accepted now that HER2-positive breast cancer is not one disease. New therapeutic strategies and a tailored approach to management are necessary to maximize patient outcomes and minimize toxicity.
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Authors
Mohsin MD, Mothaffar F. MD,