Revisiting murine models for atopic dermatitis and psoriasis with multipolar cytokine axes

•Interleukin (IL)-23/helper T cell (Th)17 and Th22 pathways are also activated in patients with AD.•There are no murine models that recapitulate all features of human AD or human psoriasis.•In a transcriptomic level, IL-23-injected mice showed the best similarity to human AD.•Investigators should be aware of the differences between the murine AD models and human AD.

Atopic dermatitis (AD) and psoriasis are one of the common skin diseases. Animal models are a powerful tool to analyze these diseases, which are complicated by multiple cytokine pathways. However, many discrepancies between the human diseases and murine models have been noticed. Therefore, investigators should be aware of the differences between the murine AD models and human AD when translating murine data to human skin diseases. This review highlights the differences between the inflammatory profiles between murine models and human diseases focusing on AD and psoriasis.