Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5665870 | Diagnostic Microbiology and Infectious Disease | 2017 | 4 Pages |
â¢HCV-Ag assay presents a strong correlation compared with RT-PCR.â¢HCV-Ag assay correctly classified all patients with sustained virological response.â¢HCV-Ag assay correctly detected all patients with treatment failures.â¢Viral load curves were almost the same both determined by RT-PCR and HCV-Ag.â¢HCV-Ag assay showed to be a reliable technique to monitor DAA treatments.
We evaluated the diagnostic usefulness of an HCV core antigen (HCV-Ag) assay in HCV-infected patients undergoing treatment with direct-acting antivirals. We analyzed 103 samples from 28 patients. Compared with RT-PCR, sensitivity was 96.2% and specificity was 100%. The correlation between techniques was excellent (Pearson coefficient: 0.871). HCV-Ag proved to be useful in patients with sustained viral response and in patients who experienced treatment failures.