Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5666345 | Human Immunology | 2017 | 5 Pages |
Killer immunoglobulin-like receptors (KIRs) have the ability to regulate natural killer (NK) cell function through inhibition/activation mechanisms. Healthy human cells express HLA class I ligands on their surface, which are recognized by NK cells to avoid spontaneous cell destruction. The associations of KIRs and/or HLA class 1 ligands in leukemic patients have been studied in some populations, with some of these studies demonstrating an association of specific types with leukemia. KIRs and their corresponding HLA class 1 ligands were investigated in Saudi patients with ALL and AML and compared to healthy controls. The homozygous A haplotype was found significantly more often in ALL patients â¤18 years-old than in control individuals. No significant association was observed in KIRs and their corresponding HLA ligands in this study.