Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5666374 | Human Immunology | 2016 | 4 Pages |
Abstract
Native American populations show higher tuberculosis (TB) mortality and infectivity rates than non-Native populations. Variants in the innate immune system seem to have an important role on TB susceptibility. The role of some innate immune system variants in TB susceptibility and/or skin test response (PPD) were investigated in the Aché, a Native American population. Complement receptor 1 and toll like receptor 9 variants were associated with anergy to PPD and protection to TB, respectively. These findings demonstrate an important role of the innate immune system variants in TB susceptibility.
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Authors
Juliana D. Lindenau, Francisco M. Salzano, Ana M. Hurtado, Kim R. Hill, Mara H. Hutz,