Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5666384 | Human Immunology | 2016 | 6 Pages |
Abstract
We have investigated HLA population alleles and haplotype frequencies for the ethnicities that comprise the contemporary population of Israel, using a large data set from the Ezer Mizion Bone Barrow Donor Registry. We genotyped 275,699 individuals at the HLA-A, -B and -DRB1 loci using HLA genotyping methods. HLA Aâ¼Bâ¼DRB1 haplotype frequencies were estimated from 19 sub-ethnic Jewish populations and other non-Jewish minorities using the maximum likelihood model, which accommodates typing ambiguities. We present overall and sub-ethnicity specific HLA diversity results of the registry, which will help guide a data-driven strategy for future registry expansion.
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Authors
Sigal Manor, Michael Halagan, Nira Shriki, Isaac Yaniv, Bracha Zisser, Martin Maiers, Abeer Madbouly, Jerry Stein,