Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5667038 | International Journal of Antimicrobial Agents | 2017 | 4 Pages |
â¢Synthesis and antimicrobial activity of cyclam derivatives are described.â¢Cyclam [H2{H2(4-CF3PhCH2)2Cyclam}](CH3COO)2â (CH3COOH)2 has bactericidal and fungicidal activities.â¢Cyclam derivatives represent a potential new class of antibiotics.
The antimicrobial activity and toxicity to nematodes of the cyclam salt [H2{H2(4-CF3PhCH2)2Cyclam}](CH3COO)2â (CH3COOH)2 were evaluated. Estimated minimum inhibitory concentrations (MICs) of 9, 261 and 15âµg/mL were obtained for Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, respectively. For selected Candida spp., the estimated MICs obtained ranged from 32âµg/mL to 63âµg/mL. Bactericidal activity was demonstrated but the compound was not reliably fungicidal. Concentrations of the cyclam salt up to 32âµg/mL did not significantly affect survival of the nematode Caenorhabditis elegans; however, concentrations equal or above this value significantly affected nematode survival in a dose-dependent manner.