Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5667222 | International Journal of Infectious Diseases | 2017 | 4 Pages |
â¢Nocardiosis is a rare gram-positive bacterial infection caused by aerobic actinomycetes most commonly observed in patients with immune defects.â¢Mortality remains high despite optimal antimicrobial treatment, especially in patients with multiple Nocardia lesions.â¢The use of adjuvant immunotherapy with interferon-gamma as adjuvant salvage therapy could be considered.
SummaryDespite advances in medical care, mortality due to cerebral Nocardia abscesses remains unacceptably high. The case of a typical immunocompromised patient, who deteriorated clinically despite optimal antimicrobial treatment, is reported here. Adjuvant immunotherapy with interferon-gamma resulted in partial restoration of the immune response and a corresponding clinical and radiographic recovery.