Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5667593 | International Journal of Infectious Diseases | 2017 | 5 Pages |
â¢New vaccines for tuberculosis are urgently needed to control this devastating disease.â¢Several novel vaccine candidates have entered clinical trials.â¢Candidates comprise subunit vaccines and whole-cell vaccines.â¢Candidates target mostly prevention of disease; some also target prevention of infection.â¢Some candidates target unexposed individuals, and others target exposed individuals.
SummaryTuberculosis (TB) remains the deadliest infectious disease. The widely used bacille Calmette-Guérin (BCG) vaccine offers only limited protection against TB. New vaccine candidates for TB include subunit vaccines and inactivated whole-cell vaccines, as well as live mycobacterial vaccines. Current developments in TB vaccines are summarized in this review.