Article ID Journal Published Year Pages File Type
5667593 International Journal of Infectious Diseases 2017 5 Pages PDF
Abstract

•New vaccines for tuberculosis are urgently needed to control this devastating disease.•Several novel vaccine candidates have entered clinical trials.•Candidates comprise subunit vaccines and whole-cell vaccines.•Candidates target mostly prevention of disease; some also target prevention of infection.•Some candidates target unexposed individuals, and others target exposed individuals.

SummaryTuberculosis (TB) remains the deadliest infectious disease. The widely used bacille Calmette-Guérin (BCG) vaccine offers only limited protection against TB. New vaccine candidates for TB include subunit vaccines and inactivated whole-cell vaccines, as well as live mycobacterial vaccines. Current developments in TB vaccines are summarized in this review.

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Life Sciences Immunology and Microbiology Applied Microbiology and Biotechnology
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