Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5667642 | Joint Bone Spine | 2016 | 4 Pages |
ObjectiveThe aim of the study was to compare the prevalence of ASCA in spondyloarthrites (SpA) patients and to investigate the association between ASCA status and disease phenotype.MethodsWe performed a case-control study including SpA individuals fulfilling the ESSG SpA criteria. The following data were collected for analysis: gender, age, disease duration, clinical or associated features of SpA, treatments, HLAB27 and ASCA status. A control group of patients without SpA was also analyzed.ResultsA total of 235Â patients with SpA and 54Â control patients were studied. The median age of SpA patients (53.6% of male patients, 52.2% of HLAB27) was 46.0 [IQR 35.0-57.0] years old. Disease duration was 60.0 [IQR 24.0-156.0] months. Inflammatory bowel diseases were observed in 11% of SpA patients. ASCA positivity was significantly higher in SpA patients than in control patients (25.5% [95%Â CI 20.1-31.6] (IgG: 9.8%; IgA: 21.7%) vs. 7.4% [95%Â CI 2.1-17.9], PÂ =Â 0.004). Multivariate analysis revealed that ASCA positivity was associated with peripheral involvement (OR: 3.30 [1.26-8.62], PÂ =Â 0.015), presence of IBD (OR: 3.43 [1.15-10.20], PÂ =Â 0.026), past of present history of uveitis (OR: 4.36 [1.08-17.64], PÂ =Â 0.039) and arthritis (OR: 3.78 [1.57-9.15], PÂ =Â 0.003).ConclusionOur results provided evidence that SpA patients had an increased prevalence of ASCA and that ASCA positivity might be associated with a particular phenotype, notably peripheral involvement and uveitis.