The diagnosis and management of the haematologic manifestations of lupus

•Haematological manifestations are common in Systemic Lupus Erythematosus.•Some of them are part of the classification criteria.•They can be related to the disease, concomitant blood disorders or iatrogenic.•These manifestations have a wide range of severity, from mild to life threatening.•Biological therapy has shown promising results, but more studies are necessary.

Haematological manifestations in systemic lupus erythematosus (SLE) are frequently observed. They are diverse and range from mild to severe. Therefore, different treatment approaches are needed from simply keeping vigilant to significant immunosuppression. Most treatment evidence is based on case-reports or small retrospective studies, as few randomized controlled trials have been performed. The development of biological therapy has opened new possible ways to treat the most severe cases but further clinical trials are necessary.In this review we consider the most common and characteristic haematological manifestations of SLE patients, focusing on their pathogenesis and management.