Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5668816 | Journal of Infection and Chemotherapy | 2017 | 4 Pages |
Abstract
Tuberculosis (TB) treatment is confounded by the range of metabolic states displayed by Mycobacterium tuberculosis, by the long duration required and by the increasing prevalence of drug-resistant strains. Latent TB infection is especially difficult to treat due to the phenotypic antibiotic resistance of non-replicating M. tuberculosis. Therefore, the development of new drugs effective against both active and latent TB infection is needed. New 1-hydroxy-2-thiopyridine derivatives were synthesized and found to be highly effective in vitro against both actively growing and dormant non-culturable M. tuberculosis. Such compounds are leads for the development of new drugs for all forms of TB including latent infection.
Keywords
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Authors
Elena G. Salina, Olga Ryabova, Anthony Vocat, Boris Nikonenko, Stewart T. Cole, Vadim Makarov,