Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5669175 | Journal of Microbiology, Immunology and Infection | 2016 | 4 Pages |
Abstract
We investigated the role of suppressor of cytokine signaling-1 (SOCS1) and SOCS3 molecules in lymph nodes from tuberculous lymphadenitis patients (LNTB). Fewer T cells were noted in LNTB cases, which also had raised chemokine (C-X-C motif) receptor 3 (CXCR3) levels. In addition, we observed a positive correlation between CXCR3 and SOCS1 expression. Our data suggest that upregulation of SOCS1 molecules may contribute to the dissemination of Mycobacterium tuberculosis from granulomas.
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Authors
Kiran I. Masood, Shahid Pervez, Martin E. Rottenberg, Beena Umar, Zahra Hasan,