Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5673442 | Microbes and Infection | 2017 | 6 Pages |
Abstract
Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role of hypoxia and HIF-1α in fungal infections is discussed regarding the innate immune response.
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Authors
Dirk Friedrich, Roger A. Fecher, Jan Rupp, George S. Jr.,