Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5673485 | Microbes and Infection | 2016 | 5 Pages |
Abstract
Invasive candidiasis often arises from translocation of endogenous yeasts from the gastrointestinal tract to the bloodstream. Here we describe that both wild type and TLR2â/â mice strains, orally administered with Candida albicans yeasts, display similar sustained high level of gut colonization when oral antibacterial treatment is present, while removal of antibiotic treatment causes a progressive clearance of yeasts in control but not in TLR2â/â mice. Fungal invasion of internal organs, following immunosuppression of colonized mice, was increased in TLR2â/â mice. These results point out to a role of TLR2 in gut protection against colonization and endogenous invasion by C. albicans.
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Authors
Daniel Prieto, Nuria Carpena, Victoria Maneu, M. Luisa Gil, Jesús Pla, Daniel Gozalbo,