Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5674757 | Trends in Parasitology | 2017 | 9 Pages |
Abstract
It is believed that infection by Toxoplasma gondii triggers a lifelong protective immunity due to the persistence of parasitic cysts which induce immunoprotection against reinfection. A review of the scientific literature since the 1950s did not yield any definitive data regarding the duration of cysts in the host or the presence of lifelong protective immunity, which led us to question this dogma. We put forward the hypothesis that sustained immunity to T. gondii requires repeated antigenic stimulations. The decline of seroprevalence recently observed in many countries might contribute to explain the loss of immunity. We address the potential consequences of this phenomenon, should it persist and worsen.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Parasitology
Authors
Solène Rougier, Jose G. Montoya, François Peyron,