Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5675403 | Virus Research | 2017 | 54 Pages |
Abstract
The paramyxo- and pneumoviruses are members of the order Mononegavirales, a group of viruses with non-segmented, negative strand RNA genomes. The polymerases of these viruses are multi-functional complexes, capable of transcribing subgenomic capped and polyadenylated mRNAs and replicating the genome. Although there is no native structure available for any complete paramyxo- or pneumovirus polymerase, functional and structural studies of a fragment of a pneumovirus polymerase protein and mutation analyses and resistance profiling of small-molecule inhibitors have generated a wealth of mechanistic information. This review integrates these data with the structure of a related polymerase, identifying similarities, differences, gaps in knowledge, and avenues for antiviral drug development.
Keywords
ParamyxovirusASPVNDVMuVRdRpPIVVSVhMPVRSVNTDHEVCTDMEVMononegaviralesRNA dependent RNA polymeraseInhibitorCappingC-terminal domainN-terminal domainPhosphoproteinMethyltransferaseconserved regionNucleoproteinSendai virusVesicular stomatitis virusNewcastle disease virusMeasles virushuman respiratory syncytial virusHuman metapneumovirusMumps virusHendra virusParainfluenza virusPolymerasePneumovirusSeV
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Authors
Rachel Fearns, Richard K. Plemper,