Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5676185 | American Journal of Obstetrics and Gynecology | 2017 | 47 Pages |
Abstract
Although meta-analysis shows a large pooled effect of Vitex agnus castus in placebo-controlled trials, the high risk of bias, high heterogeneity, and risk of publication bias of the included studies preclude a definitive conclusion. The pooled treatment effects should be viewed as merely explorative and, at best, overestimating the real treatment effect of Vitex agnus castus for premenstrual syndrome symptoms. There is a clear need for high-quality trials of appropriate size examining the effect of standardized extracts of Vitex agnus castus in comparison to placebo, selective serotonin reuptake inhibitors, and oral contraceptives to establish relative efficacy.
Related Topics
Health Sciences
Medicine and Dentistry
Medicine and Dentistry (General)
Authors
Saskia BSc, Astrid M. PhD, Roos MD, PhD, Peter F.J. MD, PhD,